The complexity of the Nrf2 pathway: beyond the antioxidant response.

摘要: The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an efficient and pivotal line of defensive to counteract environmental insults endogenous stressors. Nrf2 coordinates the basal inducible expression antioxidant Phase II detoxification enzymes adapt different stress conditions. stability cellular distribution is tightly controlled by its inhibitory binding protein Kelch-like ECH-associated 1. also regulated posttranslational, transcriptional, translational epigenetic mechanisms, as well other partners, including p62, p21 IQ motif-containing GTPase activating Many studies have demonstrated that a promising target for preventing carcinogenesis chronic diseases, cardiovascular neurodegenerative diseases pulmonary injury. However, constitutive activation in advanced cancer cells may confer drug resistance. Here, we review molecular mechanisms signalling, diverse classes activators, bioactive nutrients chemicals, functions disease relevance discuss dual role contexts.