Epigenetics in Cancer

作者: Manel Esteller

DOI: 10.1056/NEJMRA072067

关键词:

摘要: Gene transcription can be activated or inhibited by a reversible modification of the gene; this modification is termed an epigenetic change. This account of epigenetics in cancer reviews …

参考文章(102)
Jing Li, Chris Papadopoulos, Jimmy Xu, Growing Y-junction carbon nanotubes Nature. ,vol. 402, pp. 253- 254 ,(1999) , 10.1038/46214
William M Grady, Joseph Willis, Parry J Guilford, Anita K Dunbier, Tumi T Toro, Henry Lynch, Georgia Wiesner, Kelly Ferguson, Charis Eng, Jae-Gahb Park, Seong-Jin Kim, Sanford Markowitz, None, Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics. ,vol. 26, pp. 16- 17 ,(2000) , 10.1038/79120
Guo-Liang Xu, Timothy H. Bestor, Déborah Bourc'his, Chih-Lin Hsieh, Niels Tommerup, Merete Bugge, Maj Hulten, Xiaoyan Qu, James J. Russo, Evani Viegas-Péquignot, Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. ,vol. 402, pp. 187- 191 ,(1999) , 10.1038/46052
Manel Esteller, Manel Esteller, Stephen B. Baylin, James G. Herman, Paul G. Corn, A Gene Hypermethylation Profile of Human Cancer Cancer Research. ,vol. 61, pp. 3225- 3229 ,(2001)
Hilal Özdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas, None, Differential expression of selected histone modifier genes in human solid cancers BMC Genomics. ,vol. 7, pp. 90- 90 ,(2006) , 10.1186/1471-2164-7-90
J Toguchida, T Sakai, N Ohtani, D W Yandell, T P Dryja, J M Rapaport, Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. American Journal of Human Genetics. ,vol. 48, pp. 880- 888 ,(1991)
Peter W. Laird, The power and the promise of DNA methylation markers Nature Reviews Cancer. ,vol. 3, pp. 253- 266 ,(2003) , 10.1038/NRC1045
Manel Esteller, David Sidransky, Montserrat Sanchez-Cespedes, Stephen B. Baylin, Rafael Rosell, James G. Herman, Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients Cancer Research. ,vol. 59, pp. 67- 70 ,(1999)
Teresa M. Holm, Laurie Jackson-Grusby, Tobias Brambrink, Yasuhiro Yamada, William M. Rideout, Rudolf Jaenisch, Global loss of imprinting leads to widespread tumorigenesis in adult mice Cancer Cell. ,vol. 8, pp. 275- 285 ,(2005) , 10.1016/J.CCR.2005.09.007
J. Espada, E. Ballestar, R. Santoro, M. F. Fraga, A. Villar-Garea, A. Nemeth, L. Lopez-Serra, S. Ropero, A. Aranda, H. Orozco, V. Moreno, A. Juarranz, J. C. Stockert, G. Langst, I. Grummt, W. Bickmore, M. Esteller, Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells Nucleic Acids Research. ,vol. 35, pp. 2191- 2198 ,(2007) , 10.1093/NAR/GKM118