Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.

摘要: Aberrant promoter methylation and the associated loss of gene expression is a common accompaniment human cancers. Nonetheless, it has been challenging to demonstrate in any given tumour that specific was causal not consequent malignant transformation. In this regard, our attention drawn genesis gastric cancers individuals with hereditary diffuse cancer (HDGC). These harbour germline mutations encoding E-cadherin, CDH1, but their have consistently demonstrated absence heterozygosity at CDH1 locus. findings suggested hypothesis might function as 'second genetic hit' these