11 - Role of Immunohistochemical Expression of E-Cadherin in Diffuse-Type Gastric Cancer
作者： Birgit Luber , Armando Gamboa-Dominguez , Karl-Friedrich Becker , Falko Fend , Heinz Höfler
DOI: 10.1016/S1874-5784(05)80073-X
关键词:
摘要: This chapter describes the role of immunohistochemica expression E-cadherin in diffuse-type gastric cancer. is a cell-adhesion molecule expressed epithelial cells. It plays an important maintenance tissue architecture, normal development, and tumor progression. In cancer, distribution frequently deranged. staining ranges from membrane localization at cell-cell contacts to abnormal cytoplasmic combined with partial pure negative staining. Mutation-specific antibodies, reacting mutant variants, lacking exon eight or nine are available can be used screen for most frequent mutations this malignancy. Abnormal absent determined antibody clone 36 identified 84% investigated cancer samples, predominantly tumors diffuse mixed type advanced stages. The impact mutation status E-cadherin, by immunohistochemistry (IHC), specimens on patient survival discussed chapter. also discusses normal, abnormal, survival.
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sci-hub.se 参考文章(55)
Ingrid Becker, K F Becker, MH Röhrl, Gunter Minkus, K Schütze, H Höfler, None, Single-cell mutation analysis of tumors from stained histologic slides. Laboratory Investigation. ,vol. 75, pp. 801- 807 ,(1996)
Yong-Ning Zhou, Cai-Pu Xu, Biao Han, Min Li, Liang Qiao, Dian-Chun Fang, Jian-Min Yang, Expression of E-cadherin and β-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival World Journal of Gastroenterology. ,vol. 8, pp. 987- 993 ,(2002) , 10.3748/WJG.V8.I6.987
Ton N. M. Schumacher, Accessory to murder Nature. ,vol. 398, pp. 26- 27 ,(1999) , 10.1038/17927
M Sobrinho-Simoes, Geert Berx, Jc Machado, A Rocha, P Soares, F Carneiro, N Blin, S Beck, E-cadherin gene mutations provide a genetic basis for the phenotypic divergence of mixed gastric carcinomas. Laboratory Investigation. ,vol. 79, pp. 459- 465 ,(1999)
Reingard Senekowitsch-Schmidtke, Elisabeth Kremmer, Sabine Seidenschwang, Tuomo Nikula, Christos Apostolidis, Christoph Schuhmacher, Karl-Friedrich Becker, Roswitha Huber, Christof Seidl, Markus Schwaiger, Ernst Schmid, Locoregional α-Radioimmunotherapy of Intraperitoneal Tumor Cell Dissemination Using a Tumor-specific Monoclonal Antibody Clinical Cancer Research. ,vol. 9, ,(2003)
William M Grady, Joseph Willis, Parry J Guilford, Anita K Dunbier, Tumi T Toro, Henry Lynch, Georgia Wiesner, Kelly Ferguson, Charis Eng, Jae-Gahb Park, Seong-Jin Kim, Sanford Markowitz, None, Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genetics. ,vol. 26, pp. 16- 17 ,(2000) , 10.1038/79120
Karl-Friedrich Becker, Ingrid Becker, Michael J. Atkinson, Jörg R. Siewert, Ulrike Reich, Hjalmar Nekarda, Heinz Höfler, E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Research. ,vol. 54, pp. 3845- 3852 ,(1994)
Parry Guilford, Justin Hopkins, James Harraway, Maybelle McLeod, Ngahiraka McLeod, Pauline Harawira, Huriana Taite, Robin Scoular, Andrew Miller, Anthony E. Reeve, E-cadherin germline mutations in familial gastric cancer Nature. ,vol. 392, pp. 402- 405 ,(1998) , 10.1038/32918
Simon A Gayther, Kylie L Gorringe, Susan J Ramus, David Huntsman, Franco Roviello, Nicola Grehan, Jose C Machado, Enrico Pinto, Raquel Seruca, Kevin Halling, Patrick MacLeod, Steven M Powell, Charles E Jackson, Bruce AJ Ponder, Carlos Caldas, None, Identification of Germ-Line E-cadherin Mutations in Gastric Cancer Families of European Origin Cancer Research. ,vol. 58, pp. 4086- 4089 ,(1998)
Geert Berx, Karl-Friedrich Becker, Heinz Höfler, Frans van Roy, Mutations of the human E‐cadherin (CDH1) gene Human Mutation. ,vol. 12, pp. 226- 237 ,(1998) , 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D