Epigenetic Profiling of Gliomas

摘要: Glioma is understood as a genetic disease in that it caused and exacerbated by lesions specific genes control cell growth, apoptosis, angiogenesis, invasion. Epigenetics, mitotically heritable changes gene expression not due to the primary DNA sequence, provides additional mechanisms which cancer can be dysregulated. Gliomas are affected epigenetic independent of each other or interacting. The relative contribution gliomagenesis currently unknown but under active investigation. Epigenetic analyses gliomas, date mostly involving methylation, have identified new tumor suppressor genes; pinpointed for inactivation pathways controlling genome integrity, cell-cycle regulation, proliferation, invasion; uncovered regulating drug radiation resistance influence prognosis; provided rationale epigenetic-based therapies; clinically useful biomarkers response. Newer technologies such next-generation sequencing will undoubtedly bring more rapid advancements glioma epigenome profiling, allow direct integration methylation histone modification profiles. Considering enzymes critical targets drugs already clinical trials paucity information on surprising.