摘要: … of approximately 1 kb, usually located in the vicinity of genes … CpG islands located in areas downstream of promoters have … housekeeping genes are usually unmethylated 19 . Genes …
nature.com
sci-hub.se 
researchgate.net 参考文章(71)
Judith Singer-Sam, Arthur D. Riggs, X chromosome inactivation and DNA methylation. Experientia. Supplementum. ,vol. 64, pp. 358- 384 ,(1993) , 10.1007/978-3-0348-9118-9_16
E R Maher, F M Richards, A R Webster, N A Affara, A H Prowse, F Resche, S Richard, S Olschwang, Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors. American Journal of Human Genetics. ,vol. 60, pp. 765- 771 ,(1997)
Agnes Yeivin, Aharon Razin, Gene methylation patterns and expression Experientia. Supplementum. ,vol. 64, pp. 523- 568 ,(1993) , 10.1007/978-3-0348-9118-9_24
A. Aoike, N. Ohtani-Fujita, T. Sakai, Paul D Robbins, T. Fujita, N. E. Osifchin, CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene Oncogene. ,vol. 8, pp. 1063- 1067 ,(1993)
Peter L. Jones, Gert Jan C. Veenstra, Paul A. Wade, Danielle Vermaak, Stefan U. Kass, Nicoletta Landsberger, John Strouboulis, Alan P. Wolffe, Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genetics. ,vol. 19, pp. 187- 191 ,(1998) , 10.1038/561
M S Greenblatt, W P Bennett, M Hollstein, C C Harris, Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis Cancer Research. ,vol. 54, pp. 4855- 4878 ,(1994)
Stephen B. Baylln, James G. Herman, Jeremy R. Graff, Paula M. Vertino, Jean-Pierre Issa, ALTERATIONS IN DNA METHYLATION : A FUNDAMENTAL ASPECT OF NEOPLASIA Advances in Cancer Research. ,vol. 72, pp. 141- 196 ,(1998) , 10.1016/S0065-230X(08)60702-2
Andrew P. Feinberg, Melanie Ehrlich, Kenneth C. Kuo, Charles W. Gehrke, Reduced Genomic 5-Methylcytosine Content in Human Colonic Neoplasia Cancer Research. ,vol. 48, pp. 1159- 1161 ,(1988)
Joshua M. Stolker, Stephen B. Baylin, Nita Ahuja, Jean Pierre J. Issa, Avinash L. Mohan, James G. Herman, Stanley R. Hamilton, Qing Li, Association between CpG Island Methylation and Microsatellite Instability in Colorectal Cancer Cancer Research. ,vol. 57, pp. 3370- 3374 ,(1997)
Masaki Okano, Shaoping Xie, En Li, Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases Nature Genetics. ,vol. 19, pp. 219- 220 ,(1998) , 10.1038/890