Role of Immunohistochemical Expression of DNA Methyltransferases in Hepatocellular Carcinoma
作者： Mi Sun Choi , Dong Eun Song , Eunsil Yu
DOI: 10.1016/S1874-5784(05)80027-3
关键词:
摘要: The methylation of DNA is an epigenetic modification that involved in the control gene expression mammalian cells. enzymatic machinery composed three catalytically active methyltransferases (Dnmts): Dnmt1, Dnmt3a, and Dnmt3b. Dnmt1 most abundant Dnmt; it targeted to replication foci has a 10–40 fold preference for hemimethylated substrates. It seems be main enzyme responsible copying pattern after each round replication. Dnmts are overexpressed tumorigenic cells few types human tumors. Increased levels messenger RNA (mRNA) known dependent on cell proliferation seem regulated by posttranscriptional mechanism such as differential mRNA stability normal somatic In development hepatocellular carcinomas (HCCs), average Dnmt3a significantly higher noncancerous liver tissues showing chronic hepatitis or cirrhosis much HCCs than histologically tissues.
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sci-hub.se 参考文章(32)
T L Kautiainen, P A Jones, DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. Journal of Biological Chemistry. ,vol. 261, pp. 1594- 1598 ,(1986) , 10.1016/S0021-9258(17)35981-1
M. Szyf, V. Bozovic, G. Tanigawa, Growth regulation of mouse DNA methyltransferase gene expression. Journal of Biological Chemistry. ,vol. 266, pp. 10027- 10030 ,(1991) , 10.1016/S0021-9258(18)99179-9
Stephen B. Baylln, James G. Herman, Jeremy R. Graff, Paula M. Vertino, Jean-Pierre Issa, ALTERATIONS IN DNA METHYLATION : A FUNDAMENTAL ASPECT OF NEOPLASIA Advances in Cancer Research. ,vol. 72, pp. 141- 196 ,(1998) , 10.1016/S0065-230X(08)60702-2
Peter A Jones, Peter W Laird, Cancer-epigenetics comes of age Nature Genetics. ,vol. 21, pp. 163- 167 ,(1999) , 10.1038/5947
Richard Z. Chen, Ulf Pettersson, Caroline Beard, Laurie Jackson-Grusby, Rudolf Jaenisch, DNA hypomethylation leads to elevated mutation rates Nature. ,vol. 395, pp. 89- 93 ,(1998) , 10.1038/25779
Wolf Reik, Gavin Kelsey, Jörn Walter, Dissecting de novo methylation. Nature Genetics. ,vol. 23, pp. 380- 382 ,(1999) , 10.1038/70476
A. Bird, MOLECULAR BIOLOGY:DNA Methylation de Novo Science. ,vol. 286, pp. 2287- 2288 ,(1999) , 10.1126/SCIENCE.286.5448.2287
Angelo M. De Marzo, Valerie L. Marchi, Xiaohui Lin, William G. Nelson, Eddy S. Yang, Ravi Veeraswamy, Abnormal Regulation of DNA Methyltransferase Expression during Colorectal Carcinogenesis Cancer Research. ,vol. 59, pp. 3855- 3860 ,(1999)
Lin Sun, Ai-Min Hui, Yae Kanai, Michiie Sakamoto, Setsuo Hirohashi, Increased DNA Methyltransferase Expression Is Associated with an Early Stage of Human Hepatocarcinogenesis Japanese Journal of Cancer Research. ,vol. 88, pp. 1165- 1170 ,(1997) , 10.1111/J.1349-7006.1997.TB00345.X
Yoshimasa Saito, Yae Kanai, Michiie Sakamoto, Hidetsugu Saito, Hiromasa Ishii, Setsuo Hirohashi, Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology. ,vol. 33, pp. 561- 568 ,(2001) , 10.1053/JHEP.2001.22507