Gene methylation patterns and expression
作者： Agnes Yeivin , Aharon Razin
DOI: 10.1007/978-3-0348-9118-9_24
关键词:
摘要: Several lines of evidence strongly indicate that methylation cytosine residues within CpG dinucleotides are implicated in the regulation gene expression eukaryotes. Transfection experiments have shown could inhibit transcription while inhibition DNA methylase by analog 5-azacytidine induce reactivation. Furthermore, analysis pattern genes different tissues has revealed most cases existence a direct correlation between hypomethylation and activity (Razin Cedar, 1991).
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