Prognostic performance of a series of model for end-stage liver disease and respective Δ scores in patients with hepatitis B acute-on-chronic liver failure.

摘要: The present study aimed to compare the short-term prognostic performance of a series model for end-stage liver disease (MELD) and respective delta (Δ) scores scoring systems in population with acute-on-chronic hepatitis B failure (ACHBLF), investigate potential effects from antivirals. A total 77 patients ACHBLF mean age 46 years, 82% male, 58.4% receiving antivirals, were recruited this study. Δ MELDs defined as changes one week after admission. Thirty-eight (49%) (22 treated antivirals) died within three months. MELD ΔMELD survival group 19.5±4.4 0.2±3.7 respectively, those mortality 23.5±5.5 7.9±6, respectively. area under receiver operating characteristic curve (AUC) MELD, integrated (iMELD), addition serum sodium (MELD-Na), updated (upMELD), excluding international normalized ratio (INR; MELD-XI), United Kingdom (UKMELD) their 0.72, 0.81, 0.77, 0.69, 0.65, 0.77 0.86, 0.83, 0.82, 0.79 0.79, iMELD MELD-Na significantly improved accuracy (P<0.05). cut-off value 41.5 score can prognose 71% mortalities specificity 85%. In each pair models, was superior its counterpart, particularly when applied ≤30. Decreased observed all models subset although baseline characteristics comparable untreated patients, while iMELD, remained regard predictability. predicted three-month more accurately, counterparts ≤30; however, altered by thus requires optimization.