Anastomotic leakage after anterior resection for rectal cancer: risk factors.
作者： CA Bertelsen , AH Andreasen , T Jørgensen , H Harling , Danish Colorectal Cancer Group
DOI: 10.1111/J.1463-1318.2008.01711.X
关键词: Total mesorectal excision 、 Anal verge 、 Colorectal cancer 、 Medicine 、 Cohort study 、 Surgery 、 Anastomosis 、 Odds ratio 、 Perioperative 、 Multivariate analysis
摘要: Objective The study aimed to identify risk factors for clinical anastomotic leakage (AL) after anterior resection rectal cancer in a consecutive national cohort. Method All patients with an initial first diagnosis of colorectal adenocarcinoma were prospectively registered database. register included 1495 who had curative between May 2001 and December 2004. association number patient- procedure-related AL was analysed cohort design. Results Anastomotic leakages occurred 163 (11%) patients. In multivariate analysis, the significantly increased tumours located below 10 cm from anal verge if no faecal diversion undertaken (OR 5.37 5 cm (tumour level verge), 95% CI 2.10–13.7, OR 3.57 7 cm, 1.81–7.07 1.96 10 cm, 1.22–3.10), male 2.36, 1.18–4.71), smokers 1.88, 1.02–3.46), perioperative bleeding 1.05 intervals 100 ml blood loss, 1.02–1.07). Conclusion low is related level, gender, smoking bleeding. Faecal advisable total mesorectal excision order prevent AL.
sci-hub.se 参考文章(29)
Rullier, Laurent, Garrelon, Michel, Saric, Parneix, Risk factors for anastomotic leakage after resection of rectal cancer British Journal of Surgery. ,vol. 85, pp. 355- 358 ,(2003) , 10.1046/J.1365-2168.1998.00615.X
H. Harling, S. Bulow, L. N. Moller, T. Jorgensen, , Hospital volume and outcome of rectal cancer surgery in Denmark 1994-99. Colorectal Disease. ,vol. 7, pp. 90- 95 ,(2005) , 10.1111/J.1463-1318.2004.00751.X
Magnus S Ågren, Thomas L Andersen, Ursula Mirastschijski, Ingvar Syk, Christine Bruun Schiødt, Vikas Surve, Jan Lindebjerg, Jean-Marie Delaissé, None, Action of matrix metalloproteinases at restricted sites in colon anastomosis repair: an immunohistochemical and biochemical study Surgery. ,vol. 140, pp. 72- 82 ,(2006) , 10.1016/J.SURG.2005.12.013
S. Bülow, I. J. Christensen, H. Harling, O. Kronborg, C. Fenger, H. J. Nielsen, Recurrence and survival after mesorectal excision for rectal cancer British Journal of Surgery. ,vol. 90, pp. 974- 980 ,(2003) , 10.1002/BJS.4137
Lars Tue Sørensen, Henning Bay Nielsen, Arsalan Kharazmi, Finn Gottrup, Effect of smoking and abstention on oxidative burst and reactivity of neutrophils and monocytes Surgery. ,vol. 136, pp. 1047- 1053 ,(2004) , 10.1016/J.SURG.2004.04.001
Thomas Manger, Stefanie Wolff, Matthias Pross, Jörg Tautenhahn, Ingo Gastinger, Hans Lippert, Frank Marusch, Andreas Koch, Uwe Schmidt, Hubertus Wenisch, Michael Ernst, Early postoperative results of surgery for rectal carcinoma as a function of the distance of the tumor from the anal verge: results of a multicenter prospective evaluation. Langenbeck's Archives of Surgery. ,vol. 387, pp. 94- 100 ,(2002) , 10.1007/S00423-002-0298-6
Robert Gniadecki, B. Wyrwas, A. Kabala, J. Matecka, Impairment of granulation tissue formation after menopause. Journal of Endocrinological Investigation. ,vol. 19, pp. 215- 218 ,(1996) , 10.1007/BF03349870
M. T. Eriksen, A. Wibe, J. Norstein, J. Haffner, J. N. Wiig, , Anastomotic leakage following routine mesorectal excision for rectal cancer in a national cohort of patients. Colorectal Disease. ,vol. 7, pp. 51- 57 ,(2005) , 10.1111/J.1463-1318.2004.00700.X
T. Mynster, I. J. Christensen, F. Moesgaard, H. J. Nielsen, , Effects of the combination of blood transfusion and postoperative infectious complications on prognosis after surgery for colorectal cancer British Journal of Surgery. ,vol. 87, pp. 1553- 1562 ,(2002) , 10.1046/J.1365-2168.2000.01570.X
I. Gastinger, F. Marusch, R. Steinert, S. Wolff, F. Koeckerling, H. Lippert, , Protective defunctioning stoma in low anterior resection for rectal carcinoma British Journal of Surgery. ,vol. 92, pp. 1137- 1142 ,(2005) , 10.1002/BJS.5045