Intratubular calcium phosphate deposition in acute analgesic nephropathy in rabbits.

摘要: Earlier chronic studies using both animal and human autopsy material have suggested that the initial lesion of analgesic nephropathy is papillary necrosis with secondary cortical interstitial nephritis. The present study was designed to define ultrastructural changes in renal tubules exposed high levels analgesics. Female New Zealand White rabbits were given 5-7 g APC sacrificed after periods 6 36 hours. As early as hours treatment, hydroxyapatite crystallite aggregates seen impacted Segment III (straight segment) proximal tubule at cortico-medullary junction. Ultrastructural included selective calcification brush border, mitochondrial calcification, peroxisomal changes. It concluded, on basis changes, altered tubular cells may be an event nephropathy.