Identification of a Region of Frequent Loss of Heterozygosity at 11q24 in Colorectal Cancer
作者： Genevieve J. Rabiasz , J. E. Vivienne Watson , Andrew H. Wyllie , Hani Gabra , Karen J. Taylor
DOI:
关键词: Colorectal Tumors 、 Rectum 、 Colorectal cancer 、 Cancer research 、 Gene 、 Genetics 、 Biology 、 Colonic disease 、 Clinicopathological features 、 Loss of heterozygosity 、 Polymorphic locus
摘要: Loss of heterozygosity (LOH) at 11q23-qter occurs frequently in ovarian and other cancers, but for colorectal cancer, the evidence is conflicting. Seven polymorphic loci were analyzed between D11S897 D11S969 50 tumors. Two distinct LOH regions detected, suggesting possible sites tumor-suppressor genes involved neoplasia: a large centromeric region D11S925, telomeric 4.9-Mb D11S912 D11S969. There was no correlation with clinicopathological features. This analysis describes 11q23.3-24.3 first time cancer provides complementary ongoing effort to identify gene(s) involved.
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