Cytogenetics of colorectal adenocarcinomas
作者： Martine Muleris , Rémy-Jacques Salmon , Bernard Dutrillaux
DOI: 10.1016/0165-4608(90)90100-O
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摘要: Abstract The occurrence of nonrandom chromosomal anomalies in colorectal adenocarcinomas could be demonstrated from the cytogenetic study 100 cases. most frequent changes are a rearrangement chromosome 17, leading to loss its short arm and one 18. Three types tumors with abnormal karyotypes can defined. First monosomic-type near-diploid (MD), characterized by monosomy both 17p 18 mostly associated other recurrent monosomies. In two three cases, or several minor derived polyploid subclones also observed. Second (MP), which have pattern imbalance very similar that MD tumors. They derive endoreduplication followed complete disappearance original clone. Third trisomic-type (TT), lose either none, being gains entire chromosomes. These TT never undergo endoreduplication. addition, seven normal were found may constitute another category (NT). A distribution these tumor relation site was observed, since distal colon, NT underrepresented endoreduplications significantly more frequent. level mutagenesis is two-to threefold higher MP than More 95% rearrangements unbalanced, them result breakpoints located juxtacentromeric heterochromatin. good correlation between our results available molecular data on allelic losses. involvement recessive suppressor genes tumorigenesis possible relationship imbalances deviations metabolic pathways described.
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