MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER
作者： O. Delattre , D.J. Law , Y. Remvikos , X. Sastre , A.P. Feinberg
DOI: 10.1016/S0140-6736(89)90537-0
关键词:
摘要: Multiple genetic alterations were investigated in colorectal cancer, including changes DNA content, mutations ras oncogenes, and deletions involving chromosomes 5, 17, 18. A non-random association of mitotic abnormalities by site was seen, with both types occurring significantly more frequently distal tumours. In contrast, the frequency c-Ki-ras did not differ between proximal cancers. addition, associated each other change content. The data provide strong support for hypothesis that colon carcinoma might mechanisms their initiation and/or progression.
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