Updates in palliative care – overview and recent advancements in the pharmacological management of cancer pain

作者: Helen Wood , Andrew Dickman , Angela Star , Jason W Boland

DOI: 10.7861/CLINMEDICINE.18-1-17

关键词: DuloxetineCancer painPain assessmentOpioidIntensive care medicinePregabalinMedicineGabapentinTapentadolPalliative care

摘要: Pain is a common symptom in many types of cancer. Interdisciplinary team management, including pain assessment, explanation to the patient/family, treating reversible, non-pharmacological treatments and reassessment are essential. This article focuses on pharmacological management cancer pain, overviews updates recent advances this field. Both non-opioid opioid analgesia as well coanalgesics (adjuvants) reviewed. Within risks non-steroidal anti-inflammatory drugs (NSAIDs) considered recommendations for NSAIDs patients at risk gastrointestinal cardiovascular toxicity made. For analgesics, side effects opioids discussed alongside practical guidance prescribing converting between opioids. Newer such tapentadol update. Amitriptyline, duloxetine, gabapentin pregabalin, their use reviewed section.

参考文章(44)
Andrew Dickman, Drugs in Palliative Care ,(2010)
Robert G. Twycross, Palliative Care Formulary ,(2002)
Mia Schmidt-Hansen, Michael I Bennett, Stephanie Arnold, Nathan Bromham, Jennifer S Hilgart, Oxycodone for cancer‐related pain Cochrane Database of Systematic Reviews. ,vol. 8, pp. 0- 0 ,(2017) , 10.1002/14651858.CD003870.PUB6
Jason W Boland, Lucy Ziegler, Elaine G Boland, Kirstine McDermid, Michael I Bennett, None, Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? A systematic literature review. Pain. ,vol. 156, pp. 2152- 2163 ,(2015) , 10.1097/J.PAIN.0000000000000306
J W Boland, K McWilliams, S H Ahmedzai, A G Pockley, Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review. British Journal of Cancer. ,vol. 111, pp. 866- 873 ,(2014) , 10.1038/BJC.2014.384
Seema Mishra, Sushma Bhatnagar, Gaurav Nirvani Goyal, Shiv Pratap Singh Rana, Surjya Prasad Upadhya, None, A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. American Journal of Hospice and Palliative Medicine. ,vol. 29, pp. 177- 182 ,(2012) , 10.1177/1049909111412539
Wen–Pei Chang, Chia–Chin Lin, Use of opioid analgesics or sleeping medication and survival of cancer patients European Journal of Oncology Nursing. ,vol. 19, pp. 199- 206 ,(2015) , 10.1016/J.EJON.2014.11.007
Andrew N. Davies, Andrew Dickman, Colette Reid, Anna-Marie Stevens, Giovambattista Zeppetella, The management of cancer-related breakthrough pain: Recommendations of a task group of the Science Committee of the Association for Palliative Medicine of Great Britain and Ireland European Journal of Pain. ,vol. 13, pp. 331- 338 ,(2009) , 10.1016/J.EJPAIN.2008.06.014