Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? A systematic literature review.

摘要: Opioids are important in the management of pain patients with cancer. Clinicians and sometimes concerned about effect opioids on survival, which might decrease opioid prescription, compliance, symptom control. We wanted to determine whether analgesia was associated shorter survival adult systematically searched for studies that assessed regular systemic survival. identified 526 unique records, 20 articles meeting inclusion criteria. Thirteen end-of-life studies, including 11 very low-quality retrospective did not find a consistent association between analgesic treatment survival; this evidence comes from so should be interpreted caution. Seven longer-term three randomised controlled trials two prospective were included. Six these indicated likely None powered assess as primary endpoint. In view this, no definitive conclusions can made affect These data suggest while does at end life, context treatment, higher-quality endpoint, needed confirm an independent An limitation research field is relationship greater requirements may mediated by painful progressive