An overview of bioinformatics tools for epitope prediction
作者： Ruth E. Soria-Guerra , Ricardo Nieto-Gomez , Dania O. Govea-Alonso , Sergio Rosales-Mendoza
DOI: 10.1016/J.JBI.2014.11.003
关键词: Acquired immune system 、 Context (language use) 、 Vaccination 、 In silico 、 Monoclonal antibody 、 Epitope 、 Bioinformatics 、 Genome 、 Major histocompatibility complex 、 Computer science
摘要: Display Omitted Implications of bioinformatics on the development epitope-based vaccines are described.A compilation useful tools for vaccine is presented.Implications developing against hypervariable viruses described.Perspectives field identified. Exploitation recombinant DNA and sequencing technologies has led to a new concept in vaccination which isolated epitopes, capable stimulating specific immune response, have been identified used achieve advanced formulations; replacing those constituted by whole pathogen-formulations. In this context, approaches play critical role analyzing multiple genomes select protective epitopes silico. It conceived that cocktails defined or chimeric protein arrangements, including target may provide rationale design elicit convenient humoral cellular responses. This review presents comprehensive most advantageous online immunological software searchable, order facilitate vaccines. An outlook how these supporting presented. HIV influenza taken as examples promising developments viruses. Perspectives also envisioned.
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