Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases.
作者： Weibin Li , Meng Zhao , Huihui Yan , Kaiyu Wang , XIaopeng lan
DOI: 10.2174/1389557517666171002160526
关键词: Pharmacology 、 Oligonucleotide 、 Clinical trial 、 Systematic evolution of ligands by exponential enrichment 、 Anemia 、 Aptamer 、 Thrombotic thrombocytopenic purpura 、 Anemia of chronic disease 、 Medicine 、 Immunology 、 Disease
摘要: Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic evolution of ligands exponential enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many them entered into clinical trials. In present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia chronic inflammation (ACI) disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) VWD type-2B, sickle cell (SCD), particular, those that
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