Vanadium(IV) and copper(II) complexes of salicylaldimines and aromatic heterocycles: Cytotoxicity, DNA binding and DNA cleavage properties.

摘要: Abstract Five copper(II) complexes, [Cu(sal-Gly)(bipy)]( 1 ), [Cu(sal-Gly)(phen)] ( 2 [Cu(sal- l -Ala)(phen)] 3 [Cu(sal-D-Ala)(phen)] 4 -Phe)(phen)] 5 ) and five oxidovanadium(IV) [V IV O(sal-Gly)(bipy)] 6 O(sal-Gly)(phen)] 7 O(sal- -Phe)(H O)] 8 -Phe)(bipy)] 9 10 (sal = salicylaldehyde, bipy = 2,2′-bipyridine, phen = 1,10-phenanthroline) were synthesized characterized, their interaction with DNA was evaluated by different techniques: gel electrophoresis, fluorescence, UV–visible circular dichroism spectroscopy. The complexes interact calf-thymus efficiently cleave plasmid in the absence (only and/or presence of additives. cleavage ability is concentration-dependent as well metal ligand-dependent. Moreover, binding experiments show that phen-containing Cu II V O compounds display stronger than corresponding bipy analogues. present cytotoxic activity against human ovarian (A2780) breast (MCF7) carcinoma cells. Cell-growth inhibition (IC 50 , promyelocytic leukemia (HL60) cervical cancer (HeLa) cells also determined. copper much higher vanadium reference drug cisplatin (except for sal-Gly complexes); namely, phenanthroline – are ca. 10-fold more bipyridine