Water soluble copper(II) complex [Cu(dipica)(CH 3 COO)]ClO 4 : DNA binding, pH dependent DNA cleavage and cytotoxicity
作者： Somasundaram Sangeetha , Mariappan Murali
DOI: 10.1016/J.INOCHE.2015.06.032
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摘要: Abstract A mononuclear copper(II) complex [Cu(dipica)(CH3COO)]ClO4 (1), where dipica is di-(2-picolyl)amine, has been isolated. The electronic absorption (646 nm) and electron paramagnetic resonance (EPR) spectral parameters (g||, 2.223; A||, 187 × 10− 4 cm− 1; g||/A||, 119 cm) reveal that 1 possesses a near square planar geometry with CuN3O chromophore. Absorption, circular dichroic emission measurements electrochemical clearly demonstrate groove binding of to calf thymus DNA. Notably, exhibits more effective DNA (pUC 19 DNA) cleavage at acidic pH. It shows significant cytotoxicity (IC50, 55 μM) against human cervical carcinoma cells (HeLa) 48 h incubation time non-toxic healthy cells.
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