Age-associated reductions in cerebral blood flow are independent from regional atrophy.

摘要: Prior studies have demonstrated decreasing cerebral blood flow (CBF) in normal aging, but the full spatial pattern and potential mechanism of changes CBF remain to be elucidated. Specifically, existing data not been entirely consistent regarding distribution such changes, potentially a result neglecting effect age-related tissue atrophy measurements. In this work, we use pulsed arterial-spin labelling quantify regional 86 cognitively physically healthy adults, aged 23 88 years. Surface-based analyses were utilized map decline cortical thickness with advancing age, examine associations dissociations between these metrics. Our results demonstrate regionally selective reductions perfusion, involving superior-frontal, orbito-frontal, superior-parietal, middle-inferior temporal, insular, precuneus, supramarginal, lateral-occipital cingulate regions, while subcortical was relatively preserved aging. Regional effects age on differed from that grey-matter atrophy. addition, displays an interesting similarity default-mode network. These findings dissociation structural alterations specific augment our understanding mechanisms pathology older adults.