The Clinical Relevance of Beta-Receptor Blockade, Intrinsic Sympathomimetic Activity and Membrane Depressant Action

摘要: Since the original report of Powell & Slater (38) describing pharmacological properties dichloroiso-proterenol (DCI), a large number β-adrenoreceptor blocking drugs have been synthesized in last two decades (13,17, 34,35,41–44). Although originally developed for limited clinical application, their introduction medical therapeutics has truly revolutionized treatment almost all cardiovascular as well many other diseases. Success these can be easily recognized by continued interest synthesis and evaluation numerous within this broad group. only β-blockers are currently approved FDA general use, such agents under investigation country more freely available parts world. Thus, physician is often baffled to drug choice from decision should based upon rational objective considerations receptor specificity, selectivity ancillary effects. Drugs generally useful specified condition, but it known medicine that possess primary effect which forms basis main therapeutic indication, secondary effects either cause side or clinically irrelevant. The no exception rule. In chapter, relevance some factors therapy with will reviewed.