Basal and induced micronucleus frequencies in human lymphocytes with different GST and NAT2 genetic backgrounds.
作者： Alba Hernández , Noel Xamena , Sara Gutiérrez , Antonia Velázquez , Amadeu Creus
DOI: 10.1016/J.MRGENTOX.2006.02.002
关键词: Micronucleus test 、 GSTP1 、 Molecular biology 、 Lymphocyte 、 Basal (phylogenetics) 、 Genotoxicity 、 Glutathione 、 Micronucleus 、 Biology 、 Immunology 、 Allele
摘要: Abstract Basal and induced frequencies of genetic damage can be modulated by different host factors, including genes involved in phase II metabolism. Since polymorphic variants the glutathione S -transferase ( GST ) N -acetyl transferase NAT have been associated with cancer risk, we explored possible links between GSTM1 , GSTP1 GSTT1 NAT2 frequency micronuclei (MN) human lymphocytes. This exploratory study was carried out 30 thyroid patients, before after receiving an average dose 109.9 ± 1.3 mCi radioactive iodine as a co-adjuvant therapy. The results indicate that none polymorphisms studied show any kind association basal level micronuclei. When same patients were followed radioiodine exposure, significant increase MN observed practically all them (28/30), indicating genotoxic activity ionising radiation exposure. not evaluated. Nevertheless, presence slow acetylator phenotypes and, particular, NAT2*7 allele significantly lower treatment.
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