Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer.

摘要: Consumption of red meat has been associated with elevated risk colorectal cancer; however, mechanisms underlying this relationship are not well established. N-acetyltransferase 2 (NAT2) appears to activate carcinogenic heterocyclic amines found in as cigarette smoke. Genetic variation enzyme, rapid acetylation, may modulate the influence intake on cancer risk. We examined incident according NAT2 genotypes, and smoking a prospective, nested case-control study among 32,826 women enrolled Nurses' Health Study who provided prediagnostic blood specimens. matched 183 443 controls. Although acetylator genotype alone was cancer, genotypes experienced greater > or = 0.5 serving beef, pork lamb main dish per day compared less (multivariate OR 3.01; 95% CI 1.10-8.18). In contrast, slow acetylators, 0.87; 0.35-2.17). The interaction between approached statistical significance (P 0.07). Moreover, acetylators smoked 35 pack-years ate serving/day 17.6 (95% 2.0-158.3). These prospective data suggest that increase particularly genetically susceptible individuals. association supports role for mediating effect carcinogenesis.