The relationship of burn-induced hypermetabolism to central and peripheral catecholamines.

摘要: The role of brain and circulating catecholamines as mediators burn-induced hypermetabolism was investigated in two experiments. Following a 30% body surface area full-thickness open-flame burn, rats exhibited short period (3 to 4 days) anorexia followed by more prolonged (several weeks) hyperphagic-hypermetabolic response. During this hypermetabolic period, norepinephrine concentrations were increased the epinephrine levels elevated. Depletion using 6-hydroxydopamine led weight gain, but did not increase resting energy expenditure burned rats. Similarly, reduction through removal adrenal medulla resulted decreased loss only slight reductions expenditure. Therefore, these results suggest that although have full expression hypermetabolism, compounds do appear be major response burn trauma.