Effect of serotonin and throm☐ane A2 on endothelial cell proliferation: Effect of specific receptor antagonists

摘要: Abstract Platelet aggregation at sites of vascular injury releases both peptide growth factors and vasoactive compounds. Although significant attention has been focused on factors, very little is known about the mitogenic effect We evaluated serotonin (5-HT) throm☐ane A2 (TXA2) mimetic U46619 alone in combination aortic endothelial cells. Stimulation cells by 5-HT resulted an increase tritiated thymidine uptake cell number, whereas did not have any effect. However, when were exposed to compounds, potentiated When preincubated with LY281067 (a 5-HT2 receptor antagonist) or ridogrel combined TXA2 synthase inhibitor antagonist), blocked potentiating 5-HT2-induced incorporation. antagonists, effects blocked. Recent studies indicated that regenerating may release for smooth muscle cells, leading proliferation development neointima. This study suggests use antagonists inhibit attenuate formation