Alzheimer's Disease: An Overview of Recent Developments and a Look to the Future.

摘要: Alzheimer’s disease is a major public health concern, affecting an estimated 40 million people worldwide. Over the past few years, several new diagnostic tests and nomenclatures have emerged, more than 70 disease-modifying agents are in clinical trials. Naturalistic studies that include biomarkers—such as genomics, metabolomics, imaging—have yielded additional insights into mechanisms timelines of preclinical onset. This article reviews recent developments epidemiology, criteria, tests; provides updates on symptomatic therapies, ongoing prevention trials, neuropsychiatric symptom treatment options; ends with discussion prospects for cure.