Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype.

摘要: The purpose of this article is to provide a critical review the molecular alterations in pancreatic cancer that are clinically investigated as therapeutic targets and their potential impact on clinical outcomes. Adenocarcinoma exocrine pancreas generally associated with poor prognosis conventional therapies marginally effective. Advances understanding genetic regulation normal neoplastic development have led evaluation new strategies target signaling pathways cancer. Applications begun utilize biomarkers for prediction responses selection treatment options. goal accomplishing personalized tumor-specific therapy tolerable side effects patients hopefully within reach foreseeable future.