Select Biomarkers for Tumors of the Gastrointestinal Tract: Present and Future

作者: Angela N. Bartley , Stanley R. Hamilton

DOI: 10.5858/ARPA.2014-0189-RA

关键词:

摘要: Context.— Advances in molecular biomarkers of the gastrointestinal tract have contributed to a decline incidence and mortality from diseases tract. The discovery clinical validation new are important personalized cancer therapy, numerous trials currently ongoing help identify individualized therapy affecting these mechanisms they represent. Distinct pathways leading cancers colorectum, esophagus, stomach, small bowel, pancreas been identified. Using direct patient care, including selection proper testing for identification actionable mutations reporting results guide clinicians genetic counselors, is paramount. Objective.— To examine review select clinically colon, pancreas, present future with relevant ...

参考文章(136)
Cong Tan, Xiang Du, KRAS mutation testing in metastatic colorectal cancer World Journal of Gastroenterology. ,vol. 18, pp. 5171- 5180 ,(2012) , 10.3748/WJG.V18.I37.5171
Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Anne Covey, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman, Charles Fuchs, Jean L. Grem, Krystyna Kiel, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Sujata Rao, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, Constantinos Sofocleous, James Thomas, Alan P. Venook, Christopher Willett, NCCN Clinical Practice Guidelines in Oncology: colon cancer. Journal of The National Comprehensive Cancer Network. ,vol. 7, pp. 778- 831 ,(2009) , 10.6004/JNCCN.2009.0056
Richard R Keld, Yeng S Ang, Targeting key signalling pathways in oesophageal adenocarcinoma: a reality for personalised medicine? World Journal of Gastroenterology. ,vol. 17, pp. 2781- 2790 ,(2011) , 10.3748/WJG.V17.I23.2781
Nelson S. Yee, Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype. Advances in Experimental Medicine and Biology. ,vol. 779, pp. 91- 143 ,(2013) , 10.1007/978-1-4614-6176-0_5
David Capper, Anita Voigt, Gergana Bozukova, Aysel Ahadova, Philipp Kickingereder, Andreas von Deimling, Magnus von Knebel Doeberitz, Matthias Kloor, BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer. International Journal of Cancer. ,vol. 133, pp. 1624- 1630 ,(2013) , 10.1002/IJC.28183
Chen Mao, Ya‐Fang Huang, Zu‐Yao Yang, Da‐Yong Zheng, Jin‐Zhang Chen, Jin‐Ling Tang, None, KRAS p.G13D mutation and codon 12 mutations are not created equal in predicting clinical outcomes of cetuximab in metastatic colorectal cancer: a systematic review and meta-analysis. Cancer. ,vol. 119, pp. 714- 721 ,(2013) , 10.1002/CNCR.27804
Frank A. Sinicrope, Thomas C. Smyrk, David Tougeron, Stephen N. Thibodeau, Shalini Singh, Andrea Muranyi, Kandavel Shanmugam, Thomas M. Grogan, Steven R. Alberts, Qian Shi, Mutation-specific antibody detects mutant BRAFV600Eprotein expression in human colon carcinomas Cancer. ,vol. 119, pp. 2765- 2770 ,(2013) , 10.1002/CNCR.28133
Gabriel Capellà, Lourdes Farré, Isolda Casanova, Adela Mazo, Sílvia Guerrero, Ramon Mangues, K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Research. ,vol. 60, pp. 6750- 6756 ,(2000)
Markku Miettinen, Jerzy Lasota, Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis Archives of Pathology & Laboratory Medicine. ,vol. 130, pp. 1466- 1478 ,(2006) , 10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2
Kajsa Affolter, Wade Samowitz, Sheryl Tripp, Mary P. Bronner, BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma. Genes, Chromosomes and Cancer. ,vol. 52, pp. 748- 752 ,(2013) , 10.1002/GCC.22070