Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective.

摘要: Precision medicine, a concept that has recently emerged and been widely discussed, emphasizes tailoring medical care to individuals largely based on information acquired from molecular diagnostic testing. As vital aspect of precision cancer targeted therapy proven be efficacious less toxic for treatment. Colorectal (CRC) is one the most common cancers among leading causes related deaths in United States worldwide. By far, CRC successful examples field applying tests guide therapy. In this review, we summarize current guidelines anti-EGFR therapy, revisit roles pathologists an era demonstrate transition traditional “one test-one drug” assays multiplex assays, especially by using next-generation sequencing platforms clinical laboratories, discuss future perspectives tumor heterogeneity associated with resistance immune checkpoint blockage CRC.