Clinical significance of chromatin remodeling factor CHD5 expression in gastric cancer.
作者： Tadayoshi Hashimoto , Yukinori Kurokawa , Noriko Wada , Tsuyoshi Takahashi , Yasuhiro Miyazaki
关键词: Cancer cell 、 Molecular medicine 、 Cell cycle 、 Immunohistochemistry 、 Tumor suppressor gene 、 Cancer research 、 Oncogene 、 Cancer 、 Lymphovascular invasion 、 Medicine
摘要: Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as tumor suppressor gene in variety malignancies. The aim current study was to clarify clinical significance CHD5 expression gastric cancer. evaluated using immunohistochemistry (IHC) 154 specimens resected from patients with cancer January 2011 December 2013, and assessed its relationships clinicopathological characteristics survival. In vitro cell proliferation, invasion, migration assays western blotting analysis were performed role human lines. Of total patients, 57 (37.0%) exhibited low expression, significantly associated positive lymphatic invasion (P=0.032), advanced pT status (P=0.011), pStage (P=0.014). Overall survival (OS) worse compared high (hazard ratio, 1.96; 95% confidence interval, 1.09-3.45; log-rank P=0.023). Cox multivariate for OS revealed that an independent prognostic factor age pN status. vitro, upregulation cells decreased invasion. regulation multiple cancer-related targets, including p53 enhancer zeste homolog 2 (EZH2) analysis. conclusion, since regulated may be useful biomarker
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