Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer

摘要: Gastric cancer is one of the most common malignant tumors. Although improvement in chemotherapy has been achieved, clinical prognosis advanced gastric remains poor. Therefore, it increasingly important to predict and determine whether patients should or not receive neoadjuvant adjuvant chemotherapy. Leucine-rich α2-glycoprotein-1 (LRG1) overexpressed during inflammation associated with various malignancies. In this study, we assessed LRG1 expression specimens sera clarify usefulness as a biomarker cancer. This study enrolled 239 (for immunohistochemical staining; IHC) 184 ELISA) Results IHC showed that was significantly histological type, lymphatic venous invasion, tumor node factors, disease stage. Overall survival worse high group than low (P = 0.0003). Cox multivariate analysis overall revealed an independent prognostic factor 0.0258). Serum higher healthy volunteers, increased pathological stage progressed. Furthermore, significant correlation between serum level < 0.0001). Inhibition decreased cell proliferation vitro (migratory invasive capacity cells). These results suggest tumors may be useful marker patients.