CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer
作者： Raymond R.Y. Wong , Loucia K.Y. Chan , Teresa P.T. Tsang , Coral W.S. Lee , T.H. Cheung
DOI: 10.1159/000323883
关键词:
摘要: Background: The CHD5 gene located on 1p36 encodes a protein – chromodomain helicase DNA-binding 5. has been shown to be tumor suppressor candidate. This study investigated the involvement of in ovarian cancer and its clinicopathological significance. Methods: expression counterpart were determined by quantitative RT-PCR. correlation features was analyzed. Results: downregulated at least twofold 32 72 (41%) invasive epithelial carcinomas when compared 12 controls Hong Kong Chinese women. downregulation correlated clinical status (p 0.05). Survival analysis showed that patients with their tumors associated shorter disease-free total survival times those without Conclusion: shows is certain number cancers appears an adverse predictor candidate survival.
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