KRAS mutation testing in metastatic colorectal cancer
作者： Cong Tan , Xiang Du
关键词:
摘要: The KRAS oncogene is mutated in approximately 35%-45% of colorectal cancers, and mutational status testing has been highlighted recent years. most frequent mutations this gene, point substitutions codons 12 13, were validated as negative predictors response to anti-epidermal growth factor receptor antibodies. Therefore, determining the tumor samples become an essential tool for managing patients with cancers. Currently, a variety detection methods have established analyze mutation key regions gene; however, several challenges remain related standardized uniform testing, including selection samples, sample processing optimal methods. Moreover, new strategies, combination analysis BRAF, PIK3CA loss PTEN proposed by many researchers pathologists, should be promoted. In addition, we recommend that microsatellite instability, prognostic factor, added abovementioned concomitant analysis. This review provides overview biology advances testing. also addresses other aspects appropriate treatment offers insight into potential drawbacks
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