Positive feedback between oncogenic KRAS and HIF-1α confers drug resistance in colorectal cancer.
作者： Wenbing Sun , Yanzhao Wang , Fuming Lei , Wanshui Rong , Qingmin Zeng
DOI: 10.2147/OTT.S80017
关键词:
摘要: … whether resistance to EGFR inhibitors in colorectal cancer cells harboring KRAS G12V mutation is associated with hypoxia. Our data indicated that HIF-1α was induced by KRAS G12V …
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