Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop

作者: Ke Xu , Yueping Zhan , Zeting Yuan , Yanyan Qiu , Haijing Wang

DOI: 10.1016/J.YMTHE.2019.05.017

关键词: Cancer researchDrug resistancemicroRNATranscription factorSTAT3Psychological repressionColorectal cancerInterleukin 6MedicineOxaliplatin

摘要: … Acquired drug resistance is a foremost challenge in patients … CRC cells with IL-6 recombination proteins or IL-6 antibody. Our … sensitivity in CRC via suppressing the HIF-1α/miR-338-5p/…

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