Adaptive responses to antibody based therapy

摘要: Receptor tyrosine kinases (RTKs) represent a large class of protein that span the cellular membrane. There are 58 human RTKs identified which grouped into 20 distinct families based upon their ligand binding, sequence homology and structure. They controlled by binding activates intrinsic tyrosine-kinase activity. This activity leads to phosphorylation tyrosines on cytoplasmic tail, leading activation cell signaling cascades. These cascades ultimately regulate proliferation, apoptosis, migration, survival homeostasis cell. The vast majority have been directly tied etiology progression cancer. Thus, using antibodies target as cancer therapeutic strategy has intensely pursued. Although against epidermal growth factor receptor (EGFR) 2 (HER2) shown promise in clinical arena, development both acquired resistance antibody-based therapies is now well appreciated. In this review we provide an overview RTK family, biology EGFR HER2, in-depth adaptive responses undertaken cells response antibody directed these receptors. A greater understanding mechanisms relevance models will lead molecular insights overcoming circumventing therapy.