High HIF-1α expression predicts poor prognosis of patients with colon adenocarcinoma

摘要: Hypoxia inducible factor 1 alpha subunit (HIF-1α) is induced in hypoxic conditions and plays a crucial role the neoangiogenesis metastasis of cancer. In this study, we aimed to evaluate expression HIF-1α colon adenocarcinoma explore its clinicopathological characteristics prognosis. A tissue microarray involving tissues their corresponding paracancerous from 92 patients was utilized detect HIF-1α. The significantly higher than it (P < 0.001). Furthermore, similar results were observed HCT116 RKO human xenografts node mice 0.05). Additionally, augmented positively associated with TNM stage III-IV = 0.025), presence distant vascular invasion 0.048), positive lymph nodes 0.041). Kaplan-Meier survival analysis showed that up-regulation poor 5-year or 10-year multivariable Cox regression also found an independent risk for prognosis adenocarcinoma. Thus, targeting might be viable strategy treat