Phenylpyruvic acid may be a direct precursor of mandelic acid without intermediate transamination to phenylalanine
作者： B.L. Goodwin , C.R.J. Ruthven , M. Sandler
DOI: 10.1016/0006-2952(93)90656-H
关键词: Phenylpyruvic acid 、 Metabolite 、 Phenylalanine 、 Stereochemistry 、 Phenylacetic acid 、 Phenylethanolamine 、 Mandelic acid 、 Metabolism 、 Transamination 、 Chemistry
摘要: A series of compounds related to phenylalanine was administered rats. Output mandelic acid, a major but unexplained metabolite in phenylketonuria, increased after the administration phenylethanolamine or phenylpyruvic whereas phenylethylamine its excretion only marginally. Phenylacetic previously suggested as possible precursor man, almost without effect. It seems likely that acid can be formed from directly, intermediate transamination phenylalanine.
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sci-hub.se 参考文章(13)
MASAVUKI KANDA, HIROSHIGE WATANAGE, YOZO NAKATA, TANEAKI HIGASHI, YUKIYA SAKAMOTO, FORMATION OF GENTISIC ACID FROM HOMOGENTISIC ACID. V. Journal of Biochemistry. ,vol. 55, pp. 65- 71 ,(1964) , 10.1093/OXFORDJOURNALS.JBCHEM.A127842
G Kishore, M Sugumaran, C S Vaidyanathan, Metabolism of DL-(+/-)-phenylalanine by Aspergillus niger. Journal of Bacteriology. ,vol. 128, pp. 182- 191 ,(1976) , 10.1128/JB.128.1.182-191.1976
MASAYUKI KANDA, HIROSHIGE WATANABE, YUKIYA SAKAMOTO, THE FORMATION OF GENTISIC ACID FROM HOMOGENTISIC ACID. VII. FURTHER PURIFICATION AND PROPERTIES OF THE GENTISIC ACID FORMING ENZYME SYSTEM. Journal of Biochemistry. ,vol. 56, pp. 351- 354 ,(1964) , 10.1093/OXFORDJOURNALS.JBCHEM.A128000
Karl Blau, Aromatic acid excretion in phenylketonuria analysis of the unconjugated aromatic acids derived from phenylalanine Clinica Chimica Acta. ,vol. 27, pp. 5- 18 ,(1970) , 10.1016/0009-8981(70)90368-2
B.L. Goodwin, C.R.J. Ruthven, M. Sandler, Gas chromatographic estimation of urinary homovanillic and 4-hydroxy-3-methoxymandelic acids using capillary columns. Clinica Chimica Acta. ,vol. 55, pp. 111- 112 ,(1974) , 10.1016/0009-8981(74)90342-8
B.L. Goodwin, M. Sandler, Improved resolution using capillary columns Clinica Chimica Acta. ,vol. 59, pp. 253- 254 ,(1975) , 10.1016/0009-8981(75)90038-8
Malcolm Dixon, Kjell Kleppe, d-amino acid oxidase II. Specificity, competitive inhibition and reaction sequence Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. ,vol. 96, pp. 368- 382 ,(1965) , 10.1016/0005-2787(65)90557-5
David J. Edwards, Phenylethanolamine is a specific substrate for type B monoamine oxidase Life Sciences. ,vol. 23, pp. 1201- 1207 ,(1978) , 10.1016/0024-3205(78)90355-7
Vanessa Fell, John A. Hoskins, Rodney J. Pollitt, The labelling of urinary acids after oral doses of deuterated l-phenylalanine and l-tyrosine in normal subjects. quantitative studies with implications for the deuterated phenylalanine load test in phenylketonuria Clinica Chimica Acta. ,vol. 83, pp. 259- 269 ,(1978) , 10.1016/0009-8981(78)90114-6
M. Sugumaran, H. Lipke, Quinone methide formation from 4-alkylcatechols: a novel reaction catalyzed by cuticular polyphenol oxidase FEBS Letters. ,vol. 155, pp. 65- 68 ,(1983) , 10.1016/0014-5793(83)80210-5