Phenylethanolamine is a specific substrate for type B monoamine oxidase
作者： David J. Edwards
DOI: 10.1016/0024-3205(78)90355-7
关键词: Serotonin 、 Biochemistry 、 Deamination 、 Stereochemistry 、 Clorgyline 、 Metabolite 、 Phenylethanolamine 、 Selegiline 、 Substrate (chemistry) 、 Monoamine oxidase 、 Chemistry 、 General Pharmacology, Toxicology and Pharmaceutics 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: Abstract The characteristics of phenylethanolamine as both a competitive inhibitor and substrate for monoamine oxidase (MAO) were studied using rat brain liver homogenates. Although phenylethanolamine, even at high concentrations (1 mM), produced minimal inhibition MAO when serotonin (a type A MAO) was used the substrate, it potent (Ki=11 μM) deamination phenylethylamine B MAO). When deprenyl, selective MAO, found to produce single sigmoid curve low (pI50=7.5). These results indicate that is specific MAO. Identification products formed under assay conditions show converted mandelic acid phenylethylene glycol by homogenates but only latter, neutral metabolite
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