Comparison of serum cortisol concentrations in clinically normal dogs after administration of freshly reconstituted versus reconstituted and stored frozen cosyntropin.

摘要: OBJECTIVE To evaluate the biological stability of reconstituted cosyntropin after storage at -20 C for 2, 4, and 6 months. DESIGN Prospective study. ANIMALS 10 clinically normal dogs. PROCEDURE Serum cortisol concentrations in dogs were determined before 1 hour administration freshly (synthetic ACTH) or that had been stored frozen plastic syringes Cosyntropin was administered 5 micrograms/kg (2.3 micrograms/lb) body weight, i.v. RESULTS Baseline serum similar each sampling time. Compared with effects cosyntropin, did not have a significantly different effect on concentrations. CLINICAL IMPLICATIONS can be months no adverse bioactivity polypeptide.