Cortisol and aldosterone response to various doses of cosyntropin in healthy cats.

摘要: Objective—To determine the lowest dose of cosyntropin on a per body weight basis that would produce maximal cortisol and aldosterone secretion ideal timing blood sample collection after ACTH stimulation in healthy cats. Design—Randomized crossover trial. Animals—7 adult sexually intact male purpose-bred Procedures—Each cat received saline (0.9% NaCl) solution (control) 5 doses (125 μg/cat 10, 5, 2.5, 1 μg/kg [4.54, 2.27, 1.14, 0.45 μg/lb]) IV with 2-week washout period between treatments. Blood samples were obtained before (baseline) at 15, 30, 45, 60, 75, 90 minutes administration or cosyntropin. Results—Serum concentration increased significantly, compared baseline values, all doses. Lower resulted an adrenocortical response equivalent to traditional 125 μg/cat. The stimulated co...