The regulation of immunity to Leishmania major.

摘要: Experimental infection with the intracellular protozoan Leishmania major con­ stitutes a particularly versatile model for assessing role of CD4+ subset de­ velopment in host response to infectious disease. The association Thl development control infection, and Th2 cell pro­ gressive disease, has been well established. capacity manipulate out­ come, using distinct immunologic interventions, both genetically resistant susceptible mice identified key effector cytokines that must be present during time initial priming T cells order affect CD4 switch phenotype. Roles interferon-y (IFN-y), interleukin 12 (IL-12), IL-4 maturation have demonstrated, although additional undefined signals are required. Study BALB/c mouse shown fail­ ure downmodulate production is critically associated failure develop appropriate responses. Use murine L. continues elucidate new methods vaccine suggests promising system identification genes determine susceptibil ity i nfectio n.