Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.

摘要: Epilepsy comes after stroke as the most common chronic neurological disorder worldwide. Inflammation enhances neuronal hyperexcitability that could provide a background setting for development of epilepsy. The aim this study was to assess effect valproate (VAL), diclofenac (DIC), meloxicam (MEL), VAL + MEL and VAL + DIC in pentylenetetrazol (PTZ) kindled mice. Seventy mice were randomly allocated into 7 equal groups; Control, PTZ, VAL, DIC, MEL, groups. Kindling induced by PTZ (40 mg/kg, i.p.) injection every other day 17 days. drugs administered, 30 min before each till end schedule. Seizure score, latency, duration mortality rate recorded all Tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA) prostaglandin E2 (PGE2) levels well reduced glutathione (GSH) content assessed brain homogenate at decreased seizure score duration. Meanwhile, they increased latency period. TNF-α, IL-1β, MDA, PGE2 meanwhile, it GSH content. Administration homogenates. Effects combination on studied parameters significant relation VAL. produced anticonvulsant mitigated inflammation oxidative stress PTZ-kindled Interestingly, DIC rather than MEL enhanced