Circadian Misalignment and Sleep Disruption in Mild Cognitive Impairment

摘要: Background While it is evident that Alzheimer's disease associated with disturbed sleep and circadian rhythms, the extent to which such changes are in older people 'at risk' of developing dementia unknown. Objective In this study, we aimed determine whether patients mild cognitive impairment (MCI) demonstrated significant alterations timing melatonin secretion onset amount, as well architecture. Methods Thirty MCI 28 age-matched controls underwent psychiatric, medical, neuropsychological assessment, followed by overnight polysomnography dim light assessment. Participants also performed an episodic memory task while laboratory. Dim was computed using a standardized algorithm, area under curve for secretion. Sleep architecture measures including wake after latency rapid eye movement were derived. Results Patients had advanced their relative controls, but levels secreted did not differ between groups. The group greater increased latency. There differential associations cognition two groups, earlier being poorer performance patients. Conclusion Circadian misalignment disruption MCI, consistent observed disease. Such findings could be marker trajectory, may even implicated pathogenesis.