Sleep-wake changes and cognition in neurodegenerative disease.
作者： Sharon L. Naismith , Simon J.G. Lewis , Naomi L. Rogers
DOI: 10.1016/B978-0-444-53817-8.00002-5
关键词:
摘要: Abstract With the increasing aging population, neurodegenerative disorders will become more common in clinical practice. These involve multiple pathophysiological mechanisms that differentially affect cognition, mood, and physical functions. Possibly due to involvement of underlying neurobiological circuits, sleep and/or circadian (sleep–wake) changes are also this disease group. Of significance, sleep–wake often a prodromal feature predictive cognitive decline, psychiatric symptoms, quality life, need for institutional care, caregiver burden. Unfortunately, disease, few studies have included detailed polysomnography or neuropsychological assessments although some data indicate neurocognitive features related. Further required address effects pharmacological nonpharmacological treatments on functioning. Such research hopefully lead targeted early intervention approaches decline older people.
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