Fronto-striatal correlates of impaired implicit sequence learning in major depression: An fMRI study

摘要: Abstract Background Neural network models of major depression (MD) suggest that the striatum is involved in pathophysiology and linked to key cognitive clinical features. However, functional imaging studies have largely assessed prefrontal cortex utilised emotional paradigms. This study sought probe integrity fronto-striatal circuits using magnetic resonance (fMRI) conjunction with a theoretically-driven motor sequencing implicit learning (IL) task. Methods Nineteen patients MD (mean age = 56.1 years, sd = 9.8) 20 control participants age = 50.6 years, sd = 11.9) participated. A blocked fMRI paradigm was used association task which included an IL random sequence (baseline) condition. Although hypothesis driven, within between groups whole-brain analysis examine patterns compared BL Results While both activated striatum, there no significant difference controls striatal activation. Instead, subjects showed significantly greater activity middle frontal gyrus whereas exhibited superior temporal cerebellum. Limitations Most were receiving antidepressant medication when assessed. An event-related design would enabled more fine-grained related Conclusions deficits are not due primarily dysfunction. performance may depend on specific sub-components or distributed neural involving frontal, cerebellar regions.