Synthesis of some halogen-containing 1,2,4-triazolo-1,3,4-thiadiazines and their antibacterial and anticancer screening studies--part I.

摘要: Abstract A series of 7-arylidene-6-(2,4-dichloro-5-fluorophenyl)-3-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (3) were prepared by the condensation 4-amino-5-mercapto-3-substituted-1,2,4-triazoles (1) and 3-aryl-1-(2,4-dichloro-5-fluorophenyl)-2-bromo-2-propen-1-one (2). An alternative route for synthesis title compound 3 has been described. The newly synthesised compounds characterised on basis N-analyses, IR, 1H NMR mass spectral data. Some tested their antibacterial activities against Gram +ve −ve bacteria. Among 3n showed highest degree activity S. aureus evaluation LD50 value this was carried out. also screened anticancer activities. these, 3b, 3g, 3p are found to be active NCI-H460 (lung), MCF7 (breast), SF 268 (CNS) in preliminary screening studies. Further, 60-cell-line studies these results such discussed paper.