Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones
作者： Agata Siwek , Monika Wujec , Maria Dobosz , Ewa Jagiełło-Wójtowicz , Anna Chodkowska
DOI: 10.2478/S11532-007-0058-0
关键词:
摘要: By the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization 2% NaOH led to formation 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects 2 on central nervous system in mice investigated. Strong antinociceptive properties investigated derivatives observed a wide range doses.
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