Structure–activity relationship of s‐triazoles and thiadiazoles as analgesics
作者： Agata Siwek , Monika Wujec , Tomasz Plech , Edyta Kuśmierz , Ewa Jagiełło-Wójtowicz
DOI: 10.1002/HC.20605
关键词:
摘要: The influence of s-triazoles (6–9) and thiadiazoles (10–11) on the central nervous system mice in some behavioral tests was investigated. It found that compounds (10) (11) are possible candidates for further development as analgesic agents. correlation between molecular descriptors potential has been studied by using pattern recognition methods: principal component analysis (PCA) hierarchical cluster (HCA). Our results, however, showed relationship activity cannot be easily explained basis PCA HCA. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:256–264, 2010; Published online InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20605
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